On 25th July, 2023, Shaanxi Biohong Future Technology Group Co., Ltd. held a grand signing ceremony for the strategic cooperation of the global serum-free bovine muscle culture scale-up microcarrier amplification technology system launching conference and kiloliters-scale cultured meat bioreactor industrial platform in Weihai, Shandong Province. At the strategic cooperation signing ceremony, Zhang Yuanbo, member of the Standing Committee and Deputy District Chief of the Environmental and Ecological Protection Committee of Weihai City, delivered a speech. The Chairman of Biohong Future Group, Shi Wenliang, and the Chairman of Yingde Bioengineering, Li Chunyang, signed the agreement on behalf of both parties.
The guest list for this signing ceremony was impressive, including Zhang Hongchen, member of the Shaanxi Provincial Committee of the Democratic Party and special consultant to Biohong Future Group, Zhang Ruijuan, Director of Shaanxi Nutrition Society, Jin Yan, Chief Strategic Advisor of Biohong Group, Liu Hengkai, Deputy Secretary of the Party Committee and Vice President of Shandong Medical College of Pharmaceutical and Health Sciences, Jiang Fubo, Deputy General Manager of Shandong Xinhua Medical Instrument Co., Ltd. Zou Hui, a third level researcher of Weihai Market Supervision Administration, Zhang Gang, secretary of Huancui District Committee of Weihai City, member of the Standing Committee of Huancui District Committee of Weihai City, Zhang Yuanbo, deputy head of the district government, Zhang Mingxi, deputy head of Huancui District of Weihai City, secretary of the Party Committee of Yangting Town. This signing ceremony witnessed a new leap forward for Biohong Future’s industrialization platform.
The signing of this contract marks the breakthrough of cultured meat industry in China from “bottleneck” to “leading the world” by breaking through the bottleneck of cell scale cultivation, especially the large-volume culture of wall cells and serum-free culture technology, and formally stepping into the era of cultured meat kiloliters-scale industry.
Break through the boundary of natural meat sources and define a new way of the meat diet
Meat is one of the indispensable sources of nutrition in the human diet and the meat structure based on the traditional “the six domestic animals” has been formed since prehistory. However, in recent years, the greenhouse gases generated by traditional animal husbandry account for 15% of the world’s emissions, which is more than the sum of emissions from all modes of transport on earth; 30% of the annual desertification of arable land in the world is due to animal husbandry; and the animal husbandry industry consumes about 7 football pitches sized of forest vegetation in the world per minute. The demand for meat has continued to rise as a result of the population explosion, disrupting the natural ecological balance to a certain extent.
The ecological cost of the traditional meat “premium” is eroding human civilization and social progress, so people have begun to actively explore the feasibility of alternative meat. In 2013, Professor Mark Post’s team in the Netherlands successfully cultivated the world’s first cellular meat, but due to the large-scale culture of cells and cellular micro-carrier technology, the cost of this “meat” is very high, hitting 2 million.
Technology Creates a New Revolution in the Industry, Subverting the Traditional Meat Production Method
Relying on the profound technology accumulation in the field of regenerative medicine and synthetic biology, Shaanxi Biohong Future Technology Group Co., Ltd. has built four cell culture meat industrialization platforms, which are based on the technology base, technology application, and technology output, including the construction of animal source stem cell bank, the construction of engineered micro-tissue meat, the construction of 3D tissue of molded meat, and the processing of food. It has successfully overcome the problems of cell scale expansion technology, serum-free culture technology, and serum-free scale micro-carrier culture technology of cultured meat, which have overturned the traditional food structure and production mode and greatly promoted the industrialization and scale development of cultured meat in China.
In this global serum-free bovine muscle culture scale-up microcarrier amplification technology system conference, the importance of microcarrier amplification technology breakthroughs for cultured meat industrialization bottleneck breakthroughs was emphasized. Cultured meat preparation firstly obtains primary cells from animals and forms seed cells through a small amount of expansion, which can then be transferred to the microcarrier-based cellular meat scale-up cultivation program. Cells have to achieve a series of physiological processes such as attachment, expansion, differentiation, fusion, etc. on the microcarrier, which puts higher requirements on the surface structure of the microcarrier, and the scale-up of the microcarrier cell meat culture has become the biggest technical obstacle and challenge for mass production. Unlike the application of microcarriers in vaccines, recombinant proteins, and other biological agents, Biohong’s microcarriers with fully independent intellectual property rights have achieved breakthroughs and leading innovations in the selection of raw materials, preparation process, and development of cultivation process based on the benchmarking of their effectiveness, with the advantages of high biocompatibility, controllable requirements of the preparation environment, food safety protection, and extremely high cost.
In terms of safety, serum-free culture provides a reliable guarantee for cultured meat. Traditional cell culture requires the addition of foetal bovine serum to meet the special nutritional needs of cells, which, as the name suggests, is extracted from cows before they are born, and this type of preparation process faces serious challenges in terms of animal welfare, cost control, and the risk of zoonotic diseases. Achieving policy goals through precision, Biohong’s proprietary serum-free culture technology provides a reliable guarantee of food safety.
Joint efforts to open up the era of kilolitre-scale upgrade
In order to actively respond to the national “Healthy China Strategy, Food Security Strategy, and Dual Carbon Economy and Big Food” policy call and as a regenerative medicine and synthetic biology industrialization leader, Shaanxi Biohong Future Technology Group Co., Ltd. has a forward-looking layout of new protein and synthetic biotechnology industry, starting from the supply-side reform of the food industry and upgrading the quality of consumption and exploring the whole chain of scientific and technological innovation of the food structure, technological convergence, industrialization application, and business model change.
Taking cultured meat as a pilot, in order to bridge the three-level technology realization gap between samples, products, and commodities, the company seized the high point of the cultured meat global industry, Shaanxi Biohong Future Technology Group Co., Ltd. and the domestic biopharmaceutical equipment localization leader – Xinhua Medical – Yingde Biological Pharmaceutical Equipment Co., Ltd. reached deep strategic cooperation, relying on the core technology of Biohong Future microcarrier scale cell amplification system and Yingde Biological Pharmaceutical Equipment Co., Ltd. mature reactor amplification process support. This has promoted China’s kiloliters-scale process amplification and promoted the production of cultured meat quantum leap.
The completion of Biohong Future New Protein and Synthetic Biotechnology Industrial Park in Weihai, Shandong Province marks the official landing of the innovative dual industrialization base for cultured meat and plant-based artificial meat. This initiative will greatly enhance the global coverage of China’s new protein and synthetic biology technology in the food vertical, expand Weihai’s strategic map of chain extension and supplementation, and help the implementation of national top-level strategic planning.
During the event, Biohong Future also showed its industrialized and scaled-up brand matrix and product system to the representatives of major enterprises and universities and received rave reviews. According to the reporter’s understanding, its group in the field of new protein and functional/special dietary food and new protein and plant meat has listed more than 150 products. In the second half of the year, there are also nearly 150 products that have been set up and are about to come out. Marketing channels and industrialization have matured, and sales are growing at an annual rate of 100%, far exceeding that of peers.
Biohong cultured meat kiloliters-scale scale industry landed in Weihai. This will further strengthen the Biohong Future new protein and synthetic science and technology industrial park’s 10 billion output value guarantee and build up momentum and energy for the world’s first industrial base with two highly sophisticated technologies, namely plant-based cultured meat and cell-cultured meat at the same time.
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