Creative Biogene Developed ATAC-seq for The Applications of The Genome Sequencing for Fragmentation of The DNA

New York, July 01, 2019Creative Biogene, as a US-based manufacturer and provider of genomics and proteomics products and services, dedicated to helping researchers explore questions about gene discovery, regulation, and function. Creative Biogene recently launches its brand new ATAC-seq techniques that can be applied in the genome sequencing for fragmentation of the DNA.


At present, DNA transposition is a useful model for understanding other types of protein-DNA interactions, such as DNA cleavage events involved in retroviral DNA integration and immunoglobulin gene formation, and because of the Tn5-derived tools in genetic experiments, It is a useful aid. Furthermore, Tn5 is used for genome sequencing of fragmentation of DNA in ATAC-seq. A major advance in library preparation was the introduction of overactive variants of the Tn5 transposase that mediate fragmentation of double-stranded DNA and ligated synthetic oligonucleotides at both ends in a 5 minute reaction. Creative Biogene offers powerful Tn5 transposases to accelerate the research, especially for tag-based sequencing library construction.


Transposase (Tnp) Tn5 is a member of the RNase superfamily of proteins, including retroviral integrase, which can be found in the Shewanella and Escherichia bacteria. The DNA Library Preparation Kit is a complete set of optimized reagents that are ideal for converting small amounts of DNA input into an indexed library for next-generation sequencing on the Illumina platform. Developed by Creative Biogene, the DNA library preparation kit is based on the Robust Tn5 transposase, which converts the complex steps of DNA fragmentation, end-repair and adaptor ligation into a one-step enzymatic reaction, significantly reducing the initial DNA requirement and shortening. The time of library construction.


‘Creative Biogene is a leading biotechnology company providing the most affordable high quality DNA library preparation kits for customers worldwide.’ said Macia Graby, the marketing director of Creative Biogene, she also claimed, ‘With these kits, you can simultaneously complete DNA fragmentation and tagging, and complete the pre-processing of library builds in less than 2 hours, giving you the flexibility to focus on other research priorities.’


About Creative Biogene

Founded in 2004, Creative Biogene offers professional and comprehensive gene-related products and services to promote the development of biomedical and biological research. Through years of efforts, Creative Biogene has become a well-recognized industry leader under the support of our in-house scientists. Furthermore, Creative Biogene will be always committed to improving gene science with biotechnology.

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