The non-viral transfection reagents and systems market is projected to be worth USD 1.4 billion by 2030, growing at a CAGR of 9.2%, claims Roots Analysis

The non-viral transfection reagents and systems market is projected to be worth USD 1.4 billion by 2030, growing at a CAGR of 9.2%, claims Roots Analysis

An analysis of completed, ongoing and planned clinical studies related to non-viral transfection systems, featuring details on registration year, trial phase, trial status, type of sponsor, type of therapy, target therapeutic area, trial design, type of patient allocation model used, type of trial masking adopted, type of intervention, trial purpose, geographical location of trial and enrolled patient population
Given the evident immunogenicity, cytotoxicity and high production cost based concerns associated with viral vectors, companies are compelled to explore the potential of non-viral transfection systems for both research and clinical purposes

Roots Analysis has announced the addition of “Non-Viral Transfection Reagents and Systems Market, 2020-2030” report to its list of offerings.


Over time, innovative approaches surrounding the development of potential therapies using non-viral transfection systems have prompted several companies to commercialize proprietary technologies to facilitate gene transfer into cells, via a variety of physical, chemical and other non-viral methods. The growing demand for safe and effective genetically engineered ATMPs is likely to further propel the opportunity for non-viral transfection system developers.


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Key Market Insights


More than 110 companies claim to offer different types of non-viral transfection systems

The majority of players engaged in the development and commercialization of non-viral transfection systems offer reagents (52%), followed by companies offering electroporation-based transfection systems (17%) and other non-viral transfection systems (31%).


13,000+ patents related to non-viral transfection systems filed in the last three years

Over 50% of patents were filed in North America, and were primarily focused on novel transfection methods and affiliated technologies for use in therapy development, cellular reprogramming and gene editing.


300+ registered trials, as of January 2020, claim to involve non-viral transfection systems

Majority of the abovementioned clinical studies are / were focused on the evaluation of gene therapies, most of which are / were being evaluated for the treatment of oncological disorders. Further, it is worth noting that close to 50% of these trials were initiated in the last five years alone.


Over 500 cell / gene therapy developers are likely to enter into partnership with non-viral transfection system providers

It is worth noting that most of the players that are likely to enter into partnership with companies engaged in this domain are based in North America (52%), followed by those headquartered in Asia-Pacific (29%) and Europe (19%).


Revenues from the sales of non-viral transfection systems intended for research purposes, currently represent majority of the market share

By 2030, the contribution (in terms of sales-based revenues) of non-viral transfection systems for clinical applications, is anticipated to increase to 30% of the overall market. Further, the analysis presented in the report demonstrates that, in the foreseen future, around 50% of the market’s revenues are likely to come in from the sales of electroporation-based transfection systems.


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Key Questions Answered

  • Who are the leading players that offer non-viral transfection reagents and systems?
  • Which type of transfection system is likely to witness high adoption in the foreseen future?
  • What are the key factors that are likely to influence the evolution of this market?
  • What kind of initiatives have been undertaken by big pharma players engaged in this domain?
  • What kind of companies are likely to partner with non-viral transfection system providers?
  • How is the current and future market opportunity likely to be distributed across key market segments?


The USD 1.4 billion (by 2030) financial opportunity within the non-viral transfection reagents and systems market has been analyzed across the following segments:

  • Type of Transfection System
  • Transfection Reagents
  • Electroporation-Transfection Systems
  • Other non-Viral Transfection Systems


  • End-User
  • Academic and Research Institutions
  • Pharmaceutical Companies
  • Others 


  • Application Area
  • Research
  • Clinical


  • Key Geographical Regions 
  • North America
  • Europe
  • Asia-Pacific
  • Rest of the World 


The report features inputs from eminent industry stakeholders, according to whom, a significant increase in adoption of non-viral transfection systems is anticipated in clinical applications, in the foreseen future. The report includes detailed transcripts of the discussions held with the following experts:

  • George Eastwood (Vice President, Business Development, Kytopen) 
  • Claudia Andretta (Global Business Development Manager, Clinical, Polyplus-transfection)


The research includes detailed profiles of key players engaged in this domain; each profile features an overview of the company, its financial information (if available), recent developments and an informed future outlook.

  • Altogen Biosystems
  • BEX
  • Bio-Rad Laboratories
  • BTX
  • Celsion
  • Genprex
  • Inovio Pharmaceuticals
  • MaxCyte
  • MilliporeSigma
  • Nepa Gene
  • Ningbo Scientz Biotechnology
  • OZ Biosciences
  • Thermo Fisher Scientific


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  3. Global T-Cell (CAR-T, TCR, and TIL) Therapy Market (4th Edition), 2019 – 2030

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