Creative Biolabs Provides PTs Hapten Development Services to Enhance the Efficiency of Immunoassays in Antibiotics Residues Detection

An advanced peptides antibiotics (PTs) hapten design and synthesis platform has been established at the leading biotech company Creative Biolabs to push forwards the progress of antibiotics residues detection.

New York, USA – February 24, 2022 – Antibiotics are widely used in veterinary medicine to treat animal diseases, prevent microbial infections, and improve product yield, but research has confirmed that improper use of antibiotics can result in the appearance of residues in products of animal origins, such as milk, honey, meat, liver, kidney, eggs, etc., which might pose potential nephrotoxicity and neurotoxicity to human and induce resistant bacteria.

Among the various analytical means to monitor antibiotic residues, specific antigen-antibody interaction-based immunoassays represent a simple, accurate, and sensitive method. Creative Biolabs has updated the portfolio of peptides antibiotics (PTs) hapten design and synthesis services to improve the efficiency of the screening assay, especially in the antigen-antibody immunoreactive approach.

Design and Synthesis of Haptens for Bacitracin

When coupled with a carrier protein, bacitracin become immunogenic, as the protein carries multiple hapten groups that can cross-link B-cell receptors and activate T cells through peptides derived from the carrier protein. By linking bacitracin with common carrier albumen, such as bovine serum albumin (BSA), human serum albumin (HSA), mouse serum albumin (MSA), thyroprotein (TG) or hemocyanin (KLH), etc., Creative Biolabs uses it as a hapten to prepare a complete antigen. The specific monoclonal antibody obtained by immunizing the animal with this antigen has been proved applicable to detect bacitracin with higher sensitivity. Creative Biolabs selects the most appropriate site of peptide antibiotics for bacitracin haptens design and carrier protein conjugation and offers the superior anti-hapten antibodies with higher purification and affinity.

Design and Synthesis of Haptens for Colistin

As a small molecule unable to elicit animal body to produce a specific antibody, colistin could be used as a hapten in the same way as bacitracin to form an immunogen and monoclonal antibodies. Studies have shown that this mAb can specifically recognize colistin and it has negligible cross-reactivity with other antimicrobial drugs, such as bacitracin, aminoglycosides, ß-lactams, tetracyclines, sulfonamides, quinolones, and chloramphenicol. With this monoclonal antibody, Creative Biolabs has developed a rapid one-step ci-ELISA and an LFIA for colistin in animal feed and food, which are two convenient immunoassays to monitor the illegal use of colistin in animal feed and the colistin residues in animal food.

Find more information about peptides antibiotics (PTs) hapten design and synthesis at

About Creative Biolabs

To promote the development of immunoassays for the detection of drug residues, Creative Biolabs launched a center focused on small molecule antibody associated solutions and is always dedicated to assisting worldwide clients with one-stop peptide antibiotic hapten development services from hapten design, modification and synthesis, to antibody production and optimization.

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Company Name: Creative Biolabs
Contact Person: Candy Swift
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Phone: 1-631-830-6441
Country: United States